OSBPL1A

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.^[5][6][7]

AliasesOSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A

External IDsOMIM: 606730; MGI: 1927551; HomoloGene: 84746; GeneCards: OSBPL1A; OMA:OSBPL1A - orthologs

Chr.Chromosome 18 (human)^[1]

End24,397,880 bp^[1]

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OSBPL1A
Identifiers
Aliases	OSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDs	OMIM: 606730; MGI: 1927551; HomoloGene: 84746; GeneCards: OSBPL1A; OMA:OSBPL1A - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 24,162,045 bp[1] End 24,397,880 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 12,888,371 bp[2] End 13,074,898 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum internal globus pallidus inferior ganglion of vagus nerve postcentral gyrus external globus pallidus subthalamic nucleus pons pars reticulata lateral nuclear group of thalamus occipital lobe Top expressed in prefrontal cortex deep cerebellar nuclei barrel cortex medial geniculate nucleus primary motor cortex medial dorsal nucleus pontine nuclei lateral geniculate nucleus medial vestibular nucleus olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding protein binding phospholipid binding lipid binding sterol transporter activity sterol binding Cellular component endosome late endosome intracellular anatomical structure extracellular exosome cytosol membrane intracellular membrane-bounded organelle Biological process lipid transport cholesterol metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class II vesicle-mediated transport bile acid biosynthetic process sterol transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114876 64291 Ensembl ENSG00000141447 ENSMUSG00000044252 UniProt Q9BXW6 Q91XL9 RefSeq (mRNA) NM_001242508 NM_018030 NM_080597 NM_133268 NM_001252489 NM_001252490 NM_001252491 NM_001252492 NM_001252493 NM_020573 NM_207530 RefSeq (protein) NP_001229437 NP_060500 NP_542164 NP_001239418 NP_001239419 NP_001239420 NP_001239421 NP_001239422 NP_997413 Location (UCSC) Chr 18: 24.16 – 24.4 Mb Chr 18: 12.89 – 13.07 Mb PubMed search [3] [4]
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This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.^[7]