OSBPL8

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesOSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8

External IDsOMIM: 606736; MGI: 2443807; HomoloGene: 68813; GeneCards: OSBPL8; OMA:OSBPL8 - orthologs

Chr.Chromosome 12 (human)^[1]

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OSBPL8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V88
Identifiers
Aliases	OSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDs	OMIM: 606736; MGI: 2443807; HomoloGene: 68813; GeneCards: OSBPL8; OMA:OSBPL8 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.2 Start 76,351,797 bp[1] End 76,559,809 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 111,000,613 bp[2] End 111,133,110 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung lactiferous duct trabecular bone endothelial cell nipple skin of hip Achilles tendon visceral pleura trigeminal ganglion superficial temporal artery Top expressed in olfactory tubercle zygote nucleus accumbens secondary oocyte cumulus cell olfactory epithelium myocardium of ventricle retinal pigment epithelium interventricular septum aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylserine binding cholesterol binding phosphatidylinositol-4-phosphate binding lipid binding phospholipid transporter activity sterol transporter activity sterol binding Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane cortical endoplasmic reticulum endoplasmic reticulum nucleus cytosol intracellular membrane-bounded organelle Biological process activation of protein kinase B activity positive regulation of protein kinase B signaling lipid transport protein localization to nuclear pore phospholipid transport negative regulation of cell migration negative regulation of sequestering of triglyceride positive regulation of insulin receptor signaling pathway fat cell differentiation phosphatidylserine acyl-chain remodeling transport sterol transport positive regulation of glucose import Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114882 237542 Ensembl ENSG00000091039 ENSMUSG00000020189 UniProt Q9BZF1 B9EJ86 RefSeq (mRNA) NM_001003712 NM_020841 NM_001319652 NM_001319653 NM_001319655 NM_001003717 NM_175489 RefSeq (protein) NP_001003712 NP_001306581 NP_001306582 NP_001306584 NP_065892 NP_001003717 NP_780698 Location (UCSC) Chr 12: 76.35 – 76.56 Mb Chr 10: 111 – 111.13 Mb PubMed search [3] [4]
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This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.^[7]