OSTbeta

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[5][6]

AliasesSLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2
End65,053,397 bp[1]
Quick facts SLC51B, Identifiers ...
SLC51B
Identifiers
AliasesSLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2
External IDsOMIM: 612085; MGI: 3582052; HomoloGene: 18721; GeneCards: SLC51B; OMA:SLC51B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178859

NM_178933

RefSeq (protein)

NP_849190

NP_849264

Location (UCSC)Chr 15: 65.05 – 65.05 MbChr 9: 65.32 – 65.33 Mb
PubMed search[3][4]
Wikidata
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Function

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]

See also

References

Further reading

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