OTUD4

OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene.^[5][6][7]

AliasesOTUD4, DUBA6, HIN1, HSHIN1, OTU deubiquitinase 4

External IDsOMIM: 611744; MGI: 1098801; HomoloGene: 35370; GeneCards: OTUD4; OMA:OTUD4 - orthologs

Chr.Chromosome 4 (human)^[1]

End145,180,589 bp^[1]

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OTUD4
Identifiers
Aliases	OTUD4, DUBA6, HIN1, HSHIN1, OTU deubiquitinase 4
External IDs	OMIM: 611744; MGI: 1098801; HomoloGene: 35370; GeneCards: OTUD4; OMA:OTUD4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 145,110,838 bp[1] End 145,180,589 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C1|8 37.74 cM Start 80,366,247 bp[2] End 80,404,353 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle frontal gyrus Brodmann area 10 paraflocculus of cerebellum Skeletal muscle tissue of rectus abdominis frontal pole thoracic diaphragm body of tongue biceps brachii cerebellar vermis epithelium of nasopharynx Top expressed in otic placode Ileal epithelium saccule otic vesicle cumulus cell Gonadal ridge secondary oocyte tail of embryo zygote atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity protein binding hydrolase activity RNA binding molecular adaptor activity Lys63-specific deubiquitinase activity Cellular component cellular component nucleus cytoplasm Biological process protein K48-linked deubiquitination proteolysis immune system process negative regulation of toll-like receptor signaling pathway innate immune response protein K63-linked deubiquitination positive regulation of DNA demethylation regulation of protein K48-linked deubiquitination negative regulation of interleukin-1-mediated signaling pathway protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54726 73945 Ensembl ENSG00000164164 ENSMUSG00000036990 UniProt Q01804 B2RRE7 RefSeq (mRNA) NM_001102653 NM_017493 NM_199324 NM_001366057 NM_001366058 NM_001081164 NM_001256033 RefSeq (protein) NP_001096123 NP_059963 NP_001352986 NP_001352987 NP_001074633 NP_001242962 Location (UCSC) Chr 4: 145.11 – 145.18 Mb Chr 8: 80.37 – 80.4 Mb PubMed search [3] [4]
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Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells.^[7]