Oltipraz

Oltipraz is an organosulfur compound belonging to the dithiolethione class.^[1][2] It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue.^[3][4] Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity.^[3] Oltipraz has also been shown to generate superoxide radicals, which can be toxic.^[5]

ATC code

• none

CAS Number

• 64224-21-1 ^Y

PubChem CID

• 47318

ChemSpider

• 43066 ^N

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Oltipraz

Clinical data
ATC code	none
Identifiers
IUPAC name 4-methyl-5-(2-pyrazinyl)-3-dithiolethione
CAS Number	64224-21-1 Y
PubChem CID	47318
ChemSpider	43066 N
UNII	6N510JUL1Y
ChEBI	CHEBI:77319 N
ChEMBL	ChEMBL178459 N
CompTox Dashboard (EPA)	DTXSID7021079
ECHA InfoCard	100.058.833
Chemical and physical data
Formula	C8H6N2S3
Molar mass	226.33 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=C(SSC1=S)C2=NC=CN=C2
InChI InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3 N Key:CKNAQFVBEHDJQV-UHFFFAOYSA-N N
NY (what is this?)  (verify)

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