Ozagrel

Chemical compound From Wikipedia, the free encyclopedia

Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.[1]

AHFS/Drugs.comInternational Drug Names
Routes of
administrationOral
ATC code
  • none
Legal status
  • In general: ℞ (Prescription only)
Quick facts Clinical data, AHFS/Drugs.com ...
Ozagrel
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]acrylic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.122.039 Edit this at Wikidata
Chemical and physical data
FormulaC13H12N2O2
Molar mass228.251 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O
  • InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ checkY
  • Key:SHZKQBHERIJWAO-AATRIKPKSA-N checkY
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Synthesis

The free-radical halogenation of ethyl 4-methylcinnamate (1) with N-bromosuccinimide in the presence of benzoyl peroxide gives ethyl 4-bromomethylcinnamate (2).[2] Alkylation of imidazole (3) with this material gives the ethyl ester (4) of the drug, which is saponified to give ozagrel.[3][4]

References

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