P2RX5

P2X purinoceptor 5 is a protein in humans that is encoded by the P2RX5 gene.^[5][6]

AliasesP2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5

External IDsOMIM: 602836; MGI: 2137026; HomoloGene: 1924; GeneCards: P2RX5; OMA:P2RX5 - orthologs

Chr.Chromosome 17 (human)^[1]

End3,696,240 bp^[1]

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P2RX5
Identifiers
Aliases	P2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5
External IDs	OMIM: 602836; MGI: 2137026; HomoloGene: 1924; GeneCards: P2RX5; OMA:P2RX5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,672,199 bp[1] End 3,696,240 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 73,051,247 bp[2] End 73,063,511 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen lymph node appendix granulocyte mucosa of ileum blood apex of heart gastrocnemius muscle bone marrow cell glutes Top expressed in brown adipose tissue soleus muscle masseter muscle facial motor nucleus ascending aorta intercostal muscle myocardium of ventricle motor neuron muscle of thigh proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity ATP binding transmembrane signaling receptor activity purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ATP-gated ion channel activity Cellular component integral component of membrane integral component of nuclear inner membrane integral component of plasma membrane membrane plasma membrane cytosol postsynapse Biological process response to ATP positive regulation of calcium-mediated signaling ion transport positive regulation of calcium ion transport into cytosol cation transmembrane transport signal transduction nervous system development blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential cation transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5026 94045 Ensembl ENSG00000083454 ENSMUSG00000005950 UniProt Q93086 n/a RefSeq (mRNA) NM_175081 NM_001204519 NM_001204520 NM_002561 NM_175080 NM_033321 NM_001376982 NM_001376983 RefSeq (protein) NP_001191448 NP_001191449 NP_002552 NP_778255 n/a Location (UCSC) Chr 17: 3.67 – 3.7 Mb Chr 11: 73.05 – 73.06 Mb PubMed search [3] [4]
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The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.^[6]