P2RY14

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesP2RY14, BPR105, GPR105, P2Y14, purinergic receptor P2Y14

External IDsOMIM: 610116; MGI: 2155705; HomoloGene: 15769; GeneCards: P2RY14; OMA:P2RY14 - orthologs

Chr.Chromosome 3 (human)^[1]

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P2RY14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6V
Identifiers
Aliases	P2RY14, BPR105, GPR105, P2Y14, purinergic receptor P2Y14
External IDs	OMIM: 610116; MGI: 2155705; HomoloGene: 15769; GeneCards: P2RY14; OMA:P2RY14 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 151,212,117 bp[1] End 151,278,542 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 D|3 28.96 cM Start 59,021,276 bp[2] End 59,061,039 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua skin of hip endothelial cell synovial joint skin of thigh Achilles tendon endometrium gastric mucosa epithelium of colon visceral pleura Top expressed in cervix sciatic nerve spleen mesenteric lymph nodes adrenal gland external carotid artery left lung lobe Paneth cell carotid body iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled UDP receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9934 140795 Ensembl ENSG00000174944 ENSMUSG00000036381 UniProt Q15391 Q9ESG6 RefSeq (mRNA) NM_001081455 NM_014879 NM_001008497 NM_001287119 NM_001287120 NM_001287121 NM_001287122 NM_001287123 NM_001287124 NM_133200 RefSeq (protein) NP_001074924 NP_055694 NP_001008497 NP_001274048 NP_001274049 NP_001274050 NP_001274051 NP_001274052 NP_001274053 NP_573463 Location (UCSC) Chr 3: 151.21 – 151.28 Mb Chr 3: 59.02 – 59.06 Mb PubMed search [3] [4]
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The product of this gene, P2Y₁₄ belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.^[5]