P2RY4

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesP2RY4, NRU, P2P, P2Y4, UNR, pyrimidinergic receptor P2Y4

External IDsOMIM: 300038; MGI: 1926594; HomoloGene: 20568; GeneCards: P2RY4; OMA:P2RY4 - orthologs

Chr.X chromosome (human)^[1]

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P2RY4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6Q
Identifiers
Aliases	P2RY4, NRU, P2P, P2Y4, UNR, pyrimidinergic receptor P2Y4
External IDs	OMIM: 300038; MGI: 1926594; HomoloGene: 20568; GeneCards: P2RY4; OMA:P2RY4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,258,166 bp[1] End 70,260,204 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 99,633,760 bp[2] End 99,638,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle mucosa of ileum optic nerve deltoid muscle skin of abdomen rectum skin of limb skin of leg skin of hip transverse colon Top expressed in esophagus right ventricle lip tibiofemoral joint digastric muscle gastrula carotid body liver jejunum zone of skin More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled UTP receptor activity ATP binding G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane apical plasma membrane membrane glutamatergic synapse integral component of presynaptic active zone membrane Biological process positive regulation of cytosolic calcium ion concentration phospholipase C-activating G protein-coupled receptor signaling pathway transepithelial chloride transport signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway cellular response to prostaglandin E stimulus G protein-coupled receptor signaling pathway cellular response to ATP regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5030 57385 Ensembl ENSG00000186912 ENSMUSG00000044359 UniProt P51582 Q9JJS7 RefSeq (mRNA) NM_002565 NM_020621 RefSeq (protein) NP_002556 NP_065646 Location (UCSC) Chr X: 70.26 – 70.26 Mb Chr X: 99.63 – 99.64 Mb PubMed search [3] [4]
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The product of this gene, P2Y₄, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.^[6]