P4HA2

P4HA2
Identifiers
Aliases	P4HA2, prolyl 4-hydroxylase subunit alpha 2, MYP25, lncRNA-PE
External IDs	OMIM: 600608; MGI: 894286; HomoloGene: 55806; GeneCards: P4HA2; OMA:P4HA2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,295,315 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,022,491 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; tibia; ; body of pancreas; ; islet of Langerhans; ; bronchial epithelial cell; ; cartilage tissue; ; apex of heart; ; smooth muscle tissue; ; right auricle of heart; ; corpus epididymis;
	Top expressed in
	molar; ; calvaria; ; epithelium of lens; ; umbilical cord; ; gastrula; ; body of femur; ; stroma of bone marrow; ; right lung lobe; ; otic placode; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; electron transfer activity; L-ascorbic acid binding; oxidoreductase activity; protein binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; dioxygenase activity; procollagen-proline 4-dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding;
Cellular component	endoplasmic reticulum; intracellular membrane-bounded organelle; endoplasmic reticulum lumen; nucleoplasm; cytosol;
Biological process	peptidyl-proline hydroxylation; electron transport chain; peptidyl-proline hydroxylation to 4-hydroxy-L-proline;
	Sources:Amigo / QuickGO
Orthologs
	8974
	18452
	ENSG00000072682
	ENSMUSG00000018906
	O15460
	Q60716
NM_001017974; NM_001142598; NM_001142599; NM_004199; NM_001365677;
	NM_001365678; NM_001365679; NM_001365680; NM_001365681
	NM_001136076; NM_011031
NP_001017974; NP_001136070; NP_001136071; NP_004190; NP_001352606;
	NP_001352607; NP_001352608; NP_001352609; NP_001352610
	NP_001129548; NP_035161
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl 4-hydroxylase subunit alpha-2 is an enzyme that in humans is encoded by the P4HA2 gene.^[5]^[6]^[7]

AliasesP4HA2, prolyl 4-hydroxylase subunit alpha 2, MYP25, lncRNA-PE

External IDsOMIM: 600608; MGI: 894286; HomoloGene: 55806; GeneCards: P4HA2; OMA:P4HA2 - orthologs

Chr.Chromosome 5 (human)^[1]

End132,295,315 bp^[1]

Quick facts Identifiers, Aliases ...

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This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

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P4HA2

References

Related Articles

Related Articles

"Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"

"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes"

"Regulation of Type II Collagen Synthesis during Osteoarthritis by Prolyl-4-Hydroxylases : Possible Influence of Low Oxygen Levels"