PACRG

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.^[5][6]

AliasesPACRG, GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1

External IDsOMIM: 608427; MGI: 1916560; HomoloGene: 16212; GeneCards: PACRG; OMA:PACRG - orthologs

Chr.Chromosome 6 (human)^[1]

End163,315,500 bp^[1]

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PACRG
Identifiers
Aliases	PACRG, GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1
External IDs	OMIM: 608427; MGI: 1916560; HomoloGene: 16212; GeneCards: PACRG; OMA:PACRG - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q26 Start 162,727,132 bp[1] End 163,315,500 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 7.8 cM Start 10,621,941 bp[2] End 11,059,198 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa left testis right testis sperm anterior pituitary gonad mucosa of paranasal sinus apex of heart Top expressed in seminiferous tubule facial motor nucleus spermatid olfactory epithelium lumbar subsegment of spinal cord spermatocyte choroid plexus of fourth ventricle secondary oocyte anterior horn of spinal cord Epithelium of choroid plexus More reference expression data BioGPS n/a
Gene ontology Molecular function Hsp70 protein binding Hsp90 protein binding actin binding alpha-tubulin binding chaperone binding G protein-coupled receptor binding heat shock protein binding ubiquitin protein ligase binding beta-tubulin binding Cellular component cell body vesicle cytosol neuron projection sperm midpiece cilium mitochondrion nucleus Biological process negative regulation of cell death Unfolded Protein Response spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 135138 69310 Ensembl ENSG00000112530 ENSMUSG00000037196 UniProt Q96M98 Q9DAK2 RefSeq (mRNA) NM_001080378 NM_001080379 NM_152410 NM_027032 RefSeq (protein) NP_001073847 NP_001073848 NP_689623 NP_081308 Location (UCSC) Chr 6: 162.73 – 163.32 Mb Chr 17: 10.62 – 11.06 Mb PubMed search [3] [4]
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This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]