PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.^[5][6]

AliasesPAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1

External IDsOMIM: 605767; MGI: 2443160; HomoloGene: 10198; GeneCards: PAG1; OMA:PAG1 - orthologs

Chr.Chromosome 8 (human)^[1]

End81,112,068 bp^[1]

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PAG1
Identifiers
Aliases	PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDs	OMIM: 605767; MGI: 2443160; HomoloGene: 10198; GeneCards: PAG1; OMA:PAG1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 80,967,810 bp[1] End 81,112,068 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 9,752,539 bp[2] End 9,898,739 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte mucosa of ileum visceral pleura endothelial cell lower lobe of lung jejunal mucosa spinal ganglia mucosa of colon mucosa of sigmoid colon tibia Top expressed in pineal gland superior cervical ganglion ciliary body granulocyte left lung lobe substantia nigra lateral septal nucleus blood trigeminal ganglion iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH2 domain binding protein binding transmembrane receptor protein tyrosine kinase adaptor activity Cellular component integral component of membrane membrane raft plasma membrane membrane integral component of plasma membrane intracellular anatomical structure Biological process intracellular signal transduction T cell receptor signaling pathway adaptive immune response regulation of T cell activation signal transduction immune system process positive regulation of signal transduction transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of T cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55824 94212 Ensembl ENSG00000076641 ENSMUSG00000027508 UniProt Q9NWQ8 Q3U1F9 RefSeq (mRNA) NM_018440 NM_001007549 NM_001195031 NM_053182 RefSeq (protein) NP_060910 NP_001181960 NP_444412 Location (UCSC) Chr 8: 80.97 – 81.11 Mb Chr 3: 9.75 – 9.9 Mb PubMed search [3] [4]
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The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.^[6]