PARVA

Alpha-parvin is a protein that in humans is encoded by the PARVA gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesPARVA, CH-ILKBP, MXRA2, parvin alpha

External IDsOMIM: 608120; MGI: 1931144; HomoloGene: 10077; GeneCards: PARVA; OMA:PARVA - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts Available structures, PDB ...

PARVA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2R, 2VZC, 2VZD, 2VZG, 2VZI, 3KMU, 3KMW, 3REP
Identifiers
Aliases	PARVA, CH-ILKBP, MXRA2, parvin alpha
External IDs	OMIM: 608120; MGI: 1931144; HomoloGene: 10077; GeneCards: PARVA; OMA:PARVA - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.3 Start 12,377,563 bp[1] End 12,535,356 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 112,026,712 bp[2] End 112,190,899 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue stromal cell of endometrium epithelium of colon myometrium muscle layer of sigmoid colon saphenous vein gastric mucosa glomerulus tail of epididymis metanephric glomerulus Top expressed in superior cervical ganglion sciatic nerve umbilical cord uterus carotid body Epithelium of choroid plexus external carotid artery olfactory epithelium right lung lobe tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding cadherin binding Cellular component cytoplasm cytosol membrane plasma membrane cell junction Z discdkac cytoskeleton focal adhesion actin cytoskeleton nucleus lamellipodium Biological process actin cytoskeleton reorganization cilium assembly smooth muscle cell chemotaxis heterotypic cell-cell adhesion sprouting angiogenesis outflow tract septum morphogenesis establishment or maintenance of cell polarity chemotaxis actin-mediated cell contraction cell adhesion cell projection organization angiogenesis regulation of cell shape substrate adhesion-dependent cell spreading cell projection assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55742 57342 Ensembl ENSG00000197702 ENSMUSG00000030770 UniProt Q9NVD7 Q9EPC1 RefSeq (mRNA) NM_018222 NM_020606 RefSeq (protein) NP_060692 NP_065631 Location (UCSC) Chr 11: 12.38 – 12.54 Mb Chr 7: 112.03 – 112.19 Mb PubMed search [3] [4]
Wikidata
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Members of the parvin family, including PARVA, PARVB and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]^[6]