PASK

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesPASK, PASKIN, STK37, PAS domain containing serine/threonine kinase

External IDsOMIM: 607505; MGI: 2155936; HomoloGene: 9038; GeneCards: PASK; OMA:PASK - orthologs

Chr.Chromosome 2 (human)^[1]

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PASK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LL8, 3DLS
Identifiers
Aliases	PASK, PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDs	OMIM: 607505; MGI: 2155936; HomoloGene: 9038; GeneCards: PASK; OMA:PASK - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,106,099 bp[1] End 241,150,264 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 93,236,492 bp[2] End 93,271,204 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube oocyte right testis left testis secondary oocyte lymph node appendix caudate nucleus putamen nucleus accumbens Top expressed in spermatocyte spermatid otic vesicle otic placode saccule seminiferous tubule epiblast ventricular zone tail of embryo gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity protein binding ATP binding phosphatidylinositol binding lipid binding protein serine/threonine kinase activity Cellular component nucleus cytosol cytoplasm Biological process regulation of respiratory gaseous exchange protein autophosphorylation negative regulation of glycogen biosynthetic process positive regulation of translation regulation of glucagon secretion phosphorylation protein phosphorylation energy homeostasis intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23178 269224 Ensembl ENSG00000115687 ENSMUSG00000026274 UniProt Q96RG2 Q8CEE6 RefSeq (mRNA) NM_001252119 NM_001252120 NM_001252122 NM_001252124 NM_015148 NM_080850 RefSeq (protein) NP_001239048 NP_001239049 NP_001239051 NP_001239053 NP_055963 NP_543126 Location (UCSC) Chr 2: 241.11 – 241.15 Mb Chr 1: 93.24 – 93.27 Mb PubMed search [3] [4]
Wikidata
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PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM]^[8]