PAWR

PAWR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JK9
Identifiers
Aliases	PAWR, Pawr, 2310001G03Rik, PAR4, Par-4, pro-apoptotic WT1 regulator
External IDs	OMIM: 601936; MGI: 2149961; HomoloGene: 1940; GeneCards: PAWR; OMA:PAWR - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	79,690,964 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	108,250,101 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; saphenous vein; ; body of uterus; ; epithelium of colon; ; right coronary artery; ; sural nerve; ; tail of epididymis; ; left uterine tube; ; myometrium; ; parietal pleura;
	Top expressed in
	cumulus cell; ; tunica media of zone of aorta; ; Paneth cell; ; hair follicle; ; medullary collecting duct; ; renal corpuscle; ; ascending aorta; ; vestibular membrane of cochlear duct; ; calvaria; ; lacrimal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; leucine zipper domain binding; protein binding; enzyme binding; actin binding;
Cellular component	cytoplasm; nucleus; actin filament;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; actin filament bundle assembly; negative regulation of T cell receptor signaling pathway; negative regulation of T cell proliferation; positive regulation of amyloid precursor protein biosynthetic process; apoptotic signaling pathway; negative regulation of B cell proliferation; apoptotic process; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of cellular senescence; positive regulation of gene expression; negative regulation of fibroblast proliferation; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5074
	114774
	ENSG00000177425
	ENSMUSG00000035873
	Q96IZ0
	Q925B0
	NM_002583; NM_001354732; NM_001354733
	NM_054056
	NP_002574; NP_001341661; NP_001341662
	NP_473397
	Wikidata
View/Edit Human	View/Edit Mouse

PRKC apoptosis WT1 regulator protein, or Prostate apoptosis response-4, is a tumor-suppressor protein coded for in the human by the PAWR gene, that induces apoptosis in cancer cells, but not in normal cells.