PBX2

Protein found in humans From Wikipedia, the free encyclopedia

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[5][6]

AliasesPBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
End32,190,202 bp[1]
Quick facts Identifiers, Aliases ...
PBX2
Identifiers
AliasesPBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
External IDsOMIM: 176311; MGI: 1341793; HomoloGene: 48115; GeneCards: PBX2; OMA:PBX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002586

NM_017463

RefSeq (protein)

NP_002577

NP_059491

Location (UCSC)Chr 6: 32.18 – 32.19 MbChr 17: 34.81 – 34.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[6]

Interactions

PBX2 has been shown to interact with HOXA9.[7]

References

Further reading

Related Articles

Wikiwand AI