PCDH8

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.^[5][6][7]

AliasesPCDH8, ARCADLIN, PAPC, protocadherin 8

External IDsOMIM: 603580; MGI: 1306800; HomoloGene: 1943; GeneCards: PCDH8; OMA:PCDH8 - orthologs

Chr.Chromosome 13 (human)^[1]

End52,848,641 bp^[1]

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PCDH8
Identifiers
Aliases	PCDH8, ARCADLIN, PAPC, protocadherin 8
External IDs	OMIM: 603580; MGI: 1306800; HomoloGene: 1943; GeneCards: PCDH8; OMA:PCDH8 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.3 Start 52,842,889 bp[1] End 52,848,641 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D3|14 42.76 cM Start 80,004,215 bp[2] End 80,008,752 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 frontal pole endothelial cell middle temporal gyrus Brodmann area 10 dorsolateral prefrontal cortex primary visual cortex Brodmann area 9 superior frontal gyrus nucleus accumbens Top expressed in anterior amygdaloid area lateral septal nucleus substantia nigra subiculum Region I of hippocampus proper superior colliculus dorsomedial hypothalamic nucleus ventral tegmental area paraventricular nucleus of hypothalamus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component cell projection cell junction postsynaptic membrane plasma membrane membrane presynaptic membrane integral component of membrane synapse dendrite integral component of plasma membrane glutamatergic synapse integral component of postsynaptic membrane Biological process morphogenesis of embryonic epithelium somitogenesis chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling cell adhesion nervous system development regulation of synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5100 18530 Ensembl ENSG00000136099 ENSMUSG00000036422 UniProt O95206 Q7TSK3 RefSeq (mRNA) NM_032949 NM_002590 NM_001042726 NM_021543 RefSeq (protein) NP_002581 NP_116567 NP_001036191 NP_067518 Location (UCSC) Chr 13: 52.84 – 52.85 Mb Chr 14: 80 – 80.01 Mb PubMed search [3] [4]
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This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.^[7]