PCDHGC3

Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene.^[5][6][7]

AliasesPCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2, protocadherin gamma subfamily C, 3

External IDsOMIM: 603627; MGI: 1935201; HomoloGene: 31099; GeneCards: PCDHGC3; OMA:PCDHGC3 - orthologs

Chr.Chromosome 5 (human)^[1]

End141,512,977 bp^[1]

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PCDHGC3
Identifiers
Aliases	PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2, protocadherin gamma subfamily C, 3
External IDs	OMIM: 603627; MGI: 1935201; HomoloGene: 31099; GeneCards: PCDHGC3; OMA:PCDHGC3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,475,947 bp[1] End 141,512,977 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 19.67 cM Start 37,939,417 bp[2] End 37,974,926 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum anterior cingulate cortex C1 segment canal of the cervix right lung anterior pituitary right coronary artery upper lobe of left lung ascending aorta Top expressed in ganglionic eminence cerebellum cerebellar cortex white adipose tissue olfactory bulb striatum of neuraxis lung hippocampus proper superior frontal gyrus lip More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5098 93706 Ensembl ENSG00000240184 ENSMUSG00000102918 UniProt Q9UN70 n/a RefSeq (mRNA) NM_032403 NM_002588 NM_032402 NM_033581 RefSeq (protein) NP_002579 NP_115778 NP_115779 n/a Location (UCSC) Chr 5: 141.48 – 141.51 Mb Chr 18: 37.94 – 37.97 Mb PubMed search [3] [4]
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This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.^[7]