PCSK7

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.^[5][6][7]

AliasesPCSK7, LPC, PC7, PC8, SPC7, proprotein convertase subtilisin/kexin type 7

External IDsOMIM: 604872; MGI: 107421; HomoloGene: 37955; GeneCards: PCSK7; OMA:PCSK7 - orthologs

Chr.Chromosome 11 (human)^[1]

End117,232,525 bp^[1]

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PCSK7
Identifiers
Aliases	PCSK7, LPC, PC7, PC8, SPC7, proprotein convertase subtilisin/kexin type 7
External IDs	OMIM: 604872; MGI: 107421; HomoloGene: 37955; GeneCards: PCSK7; OMA:PCSK7 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 117,204,337 bp[1] End 117,232,525 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 25.32 cM Start 45,817,795 bp[2] End 45,841,024 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte sural nerve mucosa of transverse colon gastric mucosa left uterine tube body of stomach epithelium of colon buccal mucosa cell lymph node rectum Top expressed in granulocyte neural layer of retina spermatocyte large intestine right kidney colon submandibular gland epithelium of stomach lip thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi apparatus membrane trans-Golgi network Biological process protein processing peptide hormone processing proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9159 18554 Ensembl ENSG00000160613 ENSMUSG00000035382 UniProt Q16549 Q61139 RefSeq (mRNA) NM_004716 NM_001281934 NM_008794 RefSeq (protein) NP_004707 NP_001268863 NP_032820 Location (UCSC) Chr 11: 117.2 – 117.23 Mb Chr 9: 45.82 – 45.84 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140.

This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.^[7]