PD-137889

PD-137889 (N-methylhexahydrofluorenamine) is a chemical compound that is active as an NMDA receptor antagonist in the central nervous system at roughly 30 times the potency of the "flagship" of its class, ketamine,^[1] and substitutes for phencyclidine in animal studies.^[2][3][4] K_i [³H]TCP^[a] binding = 27 nM versus ketamine's K_i = 860 nM.^[5]

Quick facts Names, Identifiers ...

PD-137889

Names
IUPAC name (4aR)-N-Methyl-1,2,3,4,9,9a-hexahydro-4aH-fluoren-4a-amine
Identifiers
3D model (JSmol)	Interactive image
ChemSpider	8279807
PubChem CID	10104280
UNII	2KU62QB3UM Y
CompTox Dashboard (EPA)	DTXSID101337144
InChI InChI=1S/C14H19N/c1-15-14-9-5-4-7-12(14)10-11-6-2-3-8-13(11)14/h2-3,6,8,12,15H,4-5,7,9-10H2,1H3 Key: KQLIVVYSTDBTMZ-UHFFFAOYSA-N
SMILES c12c(cccc1)C3(NC)CCCCC3C2
Properties
Chemical formula	C14H19N
Molar mass	201.313 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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