PDCD4

PDCD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ
Identifiers
Aliases	PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
External IDs	OMIM: 608610; MGI: 107490; HomoloGene: 7879; GeneCards: PDCD4; OMA:PDCD4 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	110,900,006 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	53,918,291 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; skin of abdomen; ; skin of leg; ; rectum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; minor salivary glands; ; left ovary; ; ventricular zone; ; right ovary;
	Top expressed in
	lacrimal gland; ; submandibular gland; ; parotid gland; ; lobe of prostate; ; pyloric antrum; ; aortic valve; ; ascending aorta; ; Ileal epithelium; ; pineal gland; ; corneal stroma;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; nucleus; cytosol; nucleoplasm;
Biological process	regulation of protein metabolic process; negative regulation of cell cycle; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; negative regulation of JUN kinase activity; positive regulation of smooth muscle cell apoptotic process; negative regulation of myofibroblast differentiation; apoptotic process; positive regulation of endothelial cell apoptotic process; BMP signaling pathway; epithelial to mesenchymal transition involved in cardiac fibroblast development; negative regulation of vascular associated smooth muscle cell differentiation; positive regulation of inflammatory response; cellular response to lipopolysaccharide; negative regulation of cytokine production involved in inflammatory response; positive regulation of NIK/NF-kappaB signaling; interleukin-12-mediated signaling pathway; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	27250
	18569
	ENSG00000150593
	ENSMUSG00000024975
	Q53EL6
	Q61823
	NM_145341; NM_001199492; NM_014456
	NM_001168491; NM_001168492; NM_011050
	NP_001186421; NP_055271; NP_663314
	NP_001161963; NP_001161964; NP_035180
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.^[5]^[6] It is one of the targets of an oncomiR, MIRN21.^[7]