PDCD6IP

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesPDCD6IP, AIP1, ALIX, DRIP4, HP95, programmed cell death 6 interacting protein

External IDsOMIM: 608074; MGI: 1333753; HomoloGene: 22614; GeneCards: PDCD6IP; OMA:PDCD6IP - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts Available structures, PDB ...

PDCD6IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OEV, 2OEW, 2OEX, 2OJQ, 2R02, 2R03, 2R05, 2XS1, 2XS8, 2ZNE, 3C3O, 3C3Q, 3C3R, 3E1R, 3WUV, 4JJY
Identifiers
Aliases	PDCD6IP, AIP1, ALIX, DRIP4, HP95, programmed cell death 6 interacting protein
External IDs	OMIM: 608074; MGI: 1333753; HomoloGene: 22614; GeneCards: PDCD6IP; OMA:PDCD6IP - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.3 Start 33,798,571 bp[1] End 33,869,707 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 113,480,812 bp[2] End 113,537,327 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibial nerve stromal cell of endometrium rectum mucosa of colon gastric mucosa jejunal mucosa skin of leg monocyte mucosa of sigmoid colon Top expressed in tail of embryo genital tubercle lip vestibular membrane of cochlear duct granulocyte esophagus thymus stroma of bone marrow gastrula epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding protein dimerization activity proteinase activated receptor binding calcium-dependent protein binding Cellular component immunological synapse focal adhesion microtubule organizing center extracellular vesicle endoplasmic reticulum exit site extracellular region myelin sheath cytoskeleton melanosome membrane extracellular exosome cytoplasm cytosol actomyosin bicellular tight junction cell junction Flemming body Biological process cell cycle mitotic metaphase plate congression protein transport positive regulation of exosomal secretion viral life cycle regulation of mitotic spindle assembly ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway positive regulation of extracellular exosome assembly septum digestion after cytokinesis regulation of centrosome duplication nucleus organization multivesicular body assembly regulation of extracellular exosome assembly apoptotic process cell division viral budding via host ESCRT complex viral process actomyosin contractile ring assembly maintenance of epithelial cell apical/basal polarity bicellular tight junction assembly regulation of membrane permeability mitotic cytokinesis viral budding protein homooligomerization transport midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10015 18571 Ensembl ENSG00000170248 ENSMUSG00000032504 UniProt Q8WUM4 Q9WU78 RefSeq (mRNA) NM_001162429 NM_001256192 NM_013374 NM_001164677 NM_001164678 NM_011052 RefSeq (protein) NP_001155901 NP_001243121 NP_037506 NP_001158149 NP_001158150 NP_035182 Location (UCSC) Chr 3: 33.8 – 33.87 Mb Chr 9: 113.48 – 113.54 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.^[6]