PDE1B

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesPDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B

External IDsOMIM: 171891; MGI: 97523; HomoloGene: 37370; GeneCards: PDE1B; OMA:PDE1B - orthologs

Chr.Chromosome 12 (human)^[1]

Quick facts Available structures, PDB ...

PDE1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TAZ, 4NPV, 4NPW, 5B25
Identifiers
Aliases	PDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B
External IDs	OMIM: 171891; MGI: 97523; HomoloGene: 37370; GeneCards: PDE1B; OMA:PDE1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 54,549,601 bp[1] End 54,579,239 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F3 Start 103,411,461 bp[2] End 103,438,479 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens putamen gastric mucosa right frontal lobe prefrontal cortex Descending thoracic aorta Brodmann area 9 cingulate gyrus anterior cingulate cortex Top expressed in olfactory tubercle nucleus accumbens superior frontal gyrus globus pallidus ventricular zone perirhinal cortex granulocyte entorhinal cortex dentate gyrus of hippocampal formation granule cell superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding calmodulin binding cyclic-nucleotide phosphodiesterase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity protein binding phosphoric diester hydrolase activity hydrolase activity calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity Cellular component cytoplasm soma cytosol Biological process visual learning regulation of neurotransmitter levels cAMP catabolic process locomotory behavior response to amphetamine serotonin metabolic process monocyte differentiation regulation of dopamine metabolic process cellular response to macrophage colony-stimulating factor stimulus cGMP catabolic process cellular response to granulocyte macrophage colony-stimulating factor stimulus apoptotic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5153 18574 Ensembl ENSG00000123360 ENSMUSG00000022489 UniProt Q01064 Q01065 RefSeq (mRNA) NM_000924 NM_001165975 NM_001288768 NM_001288769 NM_001315534 NM_001315535 NM_001285890 NM_008800 NM_001357980 RefSeq (protein) NP_000915 NP_001159447 NP_001275697 NP_001275698 NP_001302463 NP_001302464 NP_001272819 NP_032826 NP_001344909 Location (UCSC) Chr 12: 54.55 – 54.58 Mb Chr 15: 103.41 – 103.44 Mb PubMed search [3] [4]
Wikidata
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