PDE4D

The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM]^[5]

PDE4D has been shown to interact with myomegalin^[6] and GNB2L1.^[7][8]

Mutations in this gene have been associated to cases of acrodysostosis.^[9]

This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.^[10]

Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker. ^{[11] [12] [13]}