PDE6D

PDE6D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KSG, 1KSH, 1KSJ, 3T5G, 3T5I, 4JHP, 4JV6, 4JV8, 4JVB, 4JVF, 5E8F, 5E80, 5F2U
Identifiers
Aliases	PDE6D, JBTS22, PDED, phosphodiesterase 6D
External IDs	OMIM: 602676; MGI: 1270843; HomoloGene: 1954; GeneCards: PDE6D; OMA:PDE6D - orthologs
EC number	3.1.4.35
Gene location (Human)
Chr.	Chromosome 2 (human)
End	231,786,272 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	86,510,351 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; C1 segment; ; ventricular zone; ; ganglionic eminence; ; caudate nucleus; ; amygdala; ; putamen; ; prefrontal cortex; ; cingulate gyrus;
	Top expressed in
	neural layer of retina; ; olfactory epithelium; ; zygote; ; tail of embryo; ; primary oocyte; ; medial ganglionic eminence; ; seminiferous tubule; ; sternocleidomastoid muscle; ; genital tubercle; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase inhibitor activity; protein binding; 3',5'-cyclic-nucleotide phosphodiesterase activity;
Cellular component	cytoplasm; cytosol; cell projection; cytoskeleton; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle; cilium;
Biological process	negative regulation of GTPase activity; response to stimulus; visual perception; sensory perception of light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5147
	18582
	ENSG00000156973
	ENSMUSG00000026239
	O43924; Q6IB24
	O55057
	NM_001291018; NM_002601
	NM_008801; NM_001360816; NM_001360817
	NP_001277947; NP_002592; NP_002592.1
	NP_032827; NP_001347745; NP_001347746
	Wikidata
View/Edit Human	View/Edit Mouse

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.^[5]^[6]^[7] PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC 3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.^[8]