Peflin

Peflin is a protein that in humans is encoded by the PEF1 gene.^[5][6][7]

AliasesPEF1, ABP32, PEF1A, penta-EF-hand domain containing 1

External IDsOMIM: 610033; MGI: 1915148; HomoloGene: 56569; GeneCards: PEF1; OMA:PEF1 - orthologs

Chr.Chromosome 1 (human)^[1]

End31,644,896 bp^[1]

Quick facts PEF1, Identifiers ...

PEF1
Identifiers
Aliases	PEF1, ABP32, PEF1A, penta-EF-hand domain containing 1
External IDs	OMIM: 610033; MGI: 1915148; HomoloGene: 56569; GeneCards: PEF1; OMA:PEF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,629,866 bp[1] End 31,644,896 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,996,351 bp[2] End 130,021,928 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland ascending aorta skin of leg skin of abdomen popliteal artery tibial arteries Descending thoracic aorta right coronary artery left coronary artery Top expressed in granulocyte right kidney duodenum lip facial motor nucleus proximal tubule superior frontal gyrus dentate gyrus of hippocampal formation granule cell esophagus muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding protein dimerization activity metal ion binding calcium-dependent cysteine-type endopeptidase activity protein heterodimerization activity RNA binding calcium-dependent protein binding molecular adaptor activity Cellular component cytoplasm extracellular exosome membrane Golgi membrane COPII vesicle coat Cul3-RING ubiquitin ligase complex endoplasmic reticulum ER to Golgi transport vesicle membrane cytoplasmic vesicle Biological process response to calcium ion proteolysis endoplasmic reticulum to Golgi vesicle-mediated transport neural crest formation neural crest cell development COPII vesicle coating positive regulation of protein monoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 553115 67898 Ensembl ENSG00000162517 ENSMUSG00000028779 UniProt Q9UBV8 Q8BFY6 RefSeq (mRNA) NM_012392 NM_001359651 NM_026441 RefSeq (protein) NP_036524 NP_001346580 NP_080717 Location (UCSC) Chr 1: 31.63 – 31.64 Mb Chr 4: 130 – 130.02 Mb PubMed search [3] [4]
Wikidata
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PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM]^[7]