PEX10

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene.[5][6] Alternative splicing results in two transcript variants encoding different isoforms.

AliasesPEX10, NALD, PBD6A, PBD6B, RNF69, peroxisomal biogenesis factor 10
End2,413,797 bp[1]
Quick facts Identifiers, Aliases ...
PEX10
Identifiers
AliasesPEX10, NALD, PBD6A, PBD6B, RNF69, peroxisomal biogenesis factor 10
External IDsOMIM: 602859; MGI: 2684988; HomoloGene: 5671; GeneCards: PEX10; OMA:PEX10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002617
NM_153818
NM_001374425
NM_001374426
NM_001374427

NM_001042407

RefSeq (protein)

NP_002608
NP_722540
NP_001361354
NP_001361355
NP_001361356

NP_001035866

Location (UCSC)Chr 1: 2.4 – 2.41 MbChr 4: 155.15 – 155.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

Peroxisome biogenesis factor 10 is involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane.[6]

Clinical significance

Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome.[6]

Interactions

PEX10 has been shown to interact with PEX12[7][8] and PEX19.[9][10]

References

Further reading

Related Articles

Wikiwand AI