PEX14

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesPEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
Quick facts Available structures, PDB ...
PEX14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
External IDsOMIM: 601791; MGI: 1927868; HomoloGene: 37936; GeneCards: PEX14; OMA:PEX14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004565

NM_019781

RefSeq (protein)

NP_004556

NP_062755

Location (UCSC)Chr 1: 10.47 – 10.63 MbChr 4: 149.04 – 149.18 Mb
PubMed search[3][4]
Wikidata
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Quick facts Peroxisomal membrane anchor protein (Pex14p) conserved region, Identifiers ...
Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
SymbolPex14_N
PfamPF04695
InterProIPR006785
Available protein structures:
PDB  IPR006785 PF04695 (ECOD; PDBsum)  
AlphaFold
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Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[6]

Interactions

PEX14 has been shown to interact with

References

Further reading

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