PEX14
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[5][6]
External IDsOMIM: 601791; MGI: 1927868; HomoloGene: 37936; GeneCards: PEX14; OMA:PEX14 - orthologs
Function
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[6]