PFDN1

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.^[5][6]

AliasesPFDN1, PDF, PFD1, prefoldin subunit 1

External IDsOMIM: 604897; MGI: 1914449; HomoloGene: 37644; GeneCards: PFDN1; OMA:PFDN1 - orthologs

Chr.Chromosome 5 (human)^[1]

End140,303,113 bp^[1]

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PFDN1
Identifiers
Aliases	PFDN1, PDF, PFD1, prefoldin subunit 1
External IDs	OMIM: 604897; MGI: 1914449; HomoloGene: 37644; GeneCards: PFDN1; OMA:PFDN1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,245,035 bp[1] End 140,303,113 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2 Start 36,536,729 bp[2] End 36,587,577 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence ventricular zone muscle of thigh islet of Langerhans gonad prefrontal cortex C1 segment apex of heart right frontal lobe Top expressed in ventromedial nucleus mammillary body lateral hypothalamus lateral septal nucleus facial motor nucleus external carotid artery maxillary prominence anterior amygdaloid area lateral geniculate nucleus arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity unfolded protein binding protein folding chaperone activity Cellular component prefoldin complex cytoplasm Biological process regulation of transcription, DNA-templated protein folding cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5201 67199 Ensembl ENSG00000113068 ENSMUSG00000024346 UniProt O60925 Q9CWM4 Q9CQF7 RefSeq (mRNA) NM_002622 NM_026027 RefSeq (protein) NP_002613 NP_080303 Location (UCSC) Chr 5: 140.25 – 140.3 Mb Chr 18: 36.54 – 36.59 Mb PubMed search [3] [4]
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This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled coils.^[6]