PFDN2

PFDN2
Identifiers
Aliases	PFDN2, PFD2, prefoldin subunit 2
External IDs	OMIM: 613466; MGI: 1276111; HomoloGene: 7887; GeneCards: PFDN2; OMA:PFDN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,118,055 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,186,822 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; anterior cingulate cortex; ; anterior pituitary; ; ganglionic eminence; ; amygdala; ; gastrocnemius muscle; ; prefrontal cortex; ; Brodmann area 9; ; hypothalamus; ; putamen;
	Top expressed in
	lateral hypothalamus; ; neural layer of retina; ; paraventricular nucleus of hypothalamus; ; central gray substance of midbrain; ; medial vestibular nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; cingulate gyrus; ; mammillary body; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein folding chaperone activity; protein binding;
Cellular component	cytoplasm; mitochondrion; nucleus; prefoldin complex; cytosol;
Biological process	positive regulation of cytoskeleton organization; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	5202
	18637
	ENSG00000143256
	ENSMUSG00000006412
	Q9UHV9
	O70591
	NM_012394
	NM_011070; NM_001360824; NM_001360825
	NP_036526
	NP_035200; NP_001347753; NP_001347754
	Wikidata
View/Edit Human	View/Edit Mouse

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene.^[5]^[6]

AliasesPFDN2, PFD2, prefoldin subunit 2

External IDsOMIM: 613466; MGI: 1276111; HomoloGene: 7887; GeneCards: PFDN2; OMA:PFDN2 - orthologs

Chr.Chromosome 1 (human)^[1]

End161,118,055 bp^[1]

Quick facts Identifiers, Aliases ...

Close

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

PFDN2

References

Further reading

Related Articles

Related Articles

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