PFKFB1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesPFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

External IDsOMIM: 311790; MGI: 107816; HomoloGene: 105654; GeneCards: PFKFB1; OMA:PFKFB1 - orthologs

Chr.X chromosome (human)^[1]

Quick facts Available structures, PDB ...

PFKFB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790; MGI: 107816; HomoloGene: 105654; GeneCards: PFKFB1; OMA:PFKFB1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.21 Start 54,932,961 bp[1] End 54,998,534 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F3 Start 149,371,225 bp[2] End 149,426,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh right lobe of liver gastrocnemius muscle Skeletal muscle tissue of rectus abdominis gonad vastus lateralis muscle muscle of arm biceps brachii testicle triceps brachii muscle Top expressed in muscle of thigh sternocleidomastoid muscle vastus lateralis muscle triceps brachii muscle masseter muscle tibialis anterior muscle temporal muscle digastric muscle gastrocnemius muscle right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding fructose-6-phosphate binding kinase activity catalytic activity protein binding identical protein binding fructose-2,6-bisphosphate 2-phosphatase activity hydrolase activity ATP binding 6-phosphofructo-2-kinase activity kinase binding Cellular component cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex Biological process gluconeogenesis response to glucagon glycolytic process phosphorylation fructose metabolic process response to glucocorticoid carbohydrate phosphorylation response to insulin positive regulation of glucokinase activity fructose 2,6-bisphosphate metabolic process animal organ regeneration response to starvation metabolism response to cAMP dephosphorylation negative regulation of glycolytic process positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5207 18639 Ensembl ENSG00000158571 ENSMUSG00000025271 UniProt P16118 P70266 RefSeq (mRNA) NM_001271804 NM_001271805 NM_002625 NM_008824 NM_001374170 NM_001374171 NM_001374172 NM_001374173 NM_001374175 RefSeq (protein) NP_001258733 NP_001258734 NP_002616 NP_032850 NP_001361099 NP_001361100 NP_001361101 NP_001361102 NP_001361104 Location (UCSC) Chr X: 54.93 – 55 Mb Chr X: 149.37 – 149.43 Mb PubMed search [3] [4]
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This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.^[6]