PHACTR3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.[5][6]

AliasesPHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
End59,847,711 bp[1]
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PHACTR3
Identifiers
AliasesPHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDsOMIM: 608725; MGI: 1921439; HomoloGene: 14482; GeneCards: PHACTR3; OMA:PHACTR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007154
NM_001177789
NM_001177790
NM_001177791
NM_028806

RefSeq (protein)

NP_001007155
NP_001171260
NP_001171261
NP_001171262
NP_083082

Location (UCSC)Chr 20: 59.58 – 59.85 MbChr 2: 177.76 – 177.98 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[6]

Interactions

PHACTR3 has been shown to interact with PPP1CA.[7]

References

Further reading

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