PHLDA2

Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.^[5][6][7]

AliasesPHLDA2, BRW1C, BWR1C, HLDA2, IPL, TSSC3, pleckstrin homology like domain family A member 2

External IDsOMIM: 602131; MGI: 1202307; HomoloGene: 2482; GeneCards: PHLDA2; OMA:PHLDA2 - orthologs

Chr.Chromosome 11 (human)^[1]

End2,929,420 bp^[1]

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PHLDA2
Identifiers
Aliases	PHLDA2, BRW1C, BWR1C, HLDA2, IPL, TSSC3, pleckstrin homology like domain family A member 2
External IDs	OMIM: 602131; MGI: 1202307; HomoloGene: 2482; GeneCards: PHLDA2; OMA:PHLDA2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 2,928,273 bp[1] End 2,929,420 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.23 cM Start 143,055,282 bp[2] End 143,056,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta mucosa of transverse colon olfactory zone of nasal mucosa stromal cell of endometrium skin of abdomen vagina ascending aorta gonad prostate testicle Top expressed in yolk sac primitive streak embryo epiblast right kidney proximal tubule embryo placenta zygote mesoderm More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 7262 22113 Ensembl ENSG00000181649 ENSG00000274538 ENSMUSG00000010760 UniProt Q53GA4 O08969 RefSeq (mRNA) NM_003311 NM_009434 RefSeq (protein) NP_003302 NP_033460 Location (UCSC) Chr 11: 2.93 – 2.93 Mb Chr 7: 143.06 – 143.06 Mb PubMed search [3] [4]
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This gene is one of several genes in the imprinted gene domain of 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.^[7]