PICALM

PICALM
Identifiers
Aliases	PICALM, CALM, CLTH, LAP, phosphatidylinositol binding clathrin assembly protein
External IDs	OMIM: 603025; MGI: 2385902; HomoloGene: 111783; GeneCards: PICALM; OMA:PICALM - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	86,069,882 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	89,862,673 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tibial arteries; ; corpus callosum; ; subcutaneous adipose tissue; ; gallbladder; ; tibial nerve; ; monocyte; ; right coronary artery; ; C1 segment; ; ascending aorta;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; interventricular septum; ; tibiofemoral joint; ; stroma of bone marrow; ; left lung lobe; ; human fetus; ; umbilical cord; ; body of femur; ; genital tubercle; ; tunica media of zone of aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	clathrin heavy chain binding; clathrin adaptor activity; clathrin binding; 1-phosphatidylinositol binding; protein binding; phospholipid binding; cadherin binding; SNARE binding; amyloid-beta binding; phosphatidylinositol-4,5-bisphosphate binding; tau protein binding; low-density lipoprotein particle receptor binding;
Cellular component	clathrin coat of coated pit; Golgi apparatus; postsynaptic membrane; membrane; neurofibrillary tangle; soma; clathrin-coated pit; AP-2 adaptor complex; presynaptic membrane; cytoplasmic vesicle; nucleus; clathrin-coated vesicle; intracellular anatomical structure; vesicle; perinuclear region of cytoplasm; cytosol; intracellular membrane-bounded organelle; early endosome; plasma membrane; cell surface; intrinsic component of membrane; clathrin-coated endocytic vesicle; endosome to plasma membrane transport vesicle; synaptic vesicle; extrinsic component of presynaptic endocytic zone membrane;
Biological process	regulation of endocytosis; endocytosis; iron ion homeostasis; receptor internalization; positive regulation of neuron death; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; negative regulation of gene expression; regulation of protein localization; negative regulation of receptor-mediated endocytosis; positive regulation of transcription, DNA-templated; endosomal transport; clathrin coat assembly; cell population proliferation; vesicle-mediated transport; axonogenesis; hemopoiesis; clathrin-dependent endocytosis; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; synaptic vesicle maturation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; vesicle cargo loading; receptor-mediated endocytosis; dendrite morphogenesis; positive regulation of amyloid-beta formation; membrane organization; iron ion import across plasma membrane; vesicle budding from membrane; learning or memory; positive regulation of GTPase activity; protein-containing complex assembly; regulation of vesicle size; membrane bending; amyloid-beta clearance by transcytosis; regulation of amyloid-beta formation; negative regulation of protein localization to plasma membrane; clathrin-coated pit assembly; negative regulation of protein localization to cell surface; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	8301
	233489
	ENSG00000073921
	ENSMUSG00000039361
	Q13492
	Q7M6Y3
	NM_001008660; NM_001206946; NM_001206947; NM_007166
NM_001252520; NM_001252521; NM_001252522; NM_001252523; NM_001252524;
	NM_146194; NM_001360867
	NP_001008660; NP_001193875; NP_001193876; NP_009097; NP_001008660.1
NP_001239449; NP_001239450; NP_001239451; NP_001239452; NP_001239453;
	NP_666306; NP_001347796
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.^[5]