PIGC

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.^[5][6][7]

AliasesPIGC, GPI2, phosphatidylinositol glycan anchor biosynthesis class C, MRT62, GPIBD16

External IDsOMIM: 601730; MGI: 1914542; HomoloGene: 7109; GeneCards: PIGC; OMA:PIGC - orthologs

Chr.Chromosome 1 (human)^[1]

End172,444,086 bp^[1]

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PIGC
Identifiers
Aliases	PIGC, GPI2, phosphatidylinositol glycan anchor biosynthesis class C, MRT62, GPIBD16
External IDs	OMIM: 601730; MGI: 1914542; HomoloGene: 7109; GeneCards: PIGC; OMA:PIGC - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.3 Start 172,370,189 bp[1] End 172,444,086 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.1 Start 161,796,755 bp[2] End 161,801,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon skin of leg skin of abdomen islet of Langerhans monocyte skin of thigh nipple body of pancreas bone marrow hair follicle Top expressed in seminal vesicula cornea renal corpuscle calvaria epithelium of lens temporal muscle upper arm molar primary oocyte triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity phosphatidylinositol N-acetylglucosaminyltransferase activity catalytic activity glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex endoplasmic reticulum membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5279 67292 Ensembl ENSG00000135845 ENSMUSG00000026698 UniProt Q92535 Q9CXR4 RefSeq (mRNA) NM_153747 NM_002642 NM_001039045 NM_026078 RefSeq (protein) NP_002633 NP_714969 NP_001034134 NP_080354 Location (UCSC) Chr 1: 172.37 – 172.44 Mb Chr 1: 161.8 – 161.8 Mb PubMed search [3] [4]
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This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.^[7]