PIGH

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene.^[5][6] The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.^[7]

AliasesPIGH, GPI-H, phosphatidylinositol glycan anchor biosynthesis class H

External IDsOMIM: 600154; MGI: 99463; HomoloGene: 3361; GeneCards: PIGH; OMA:PIGH - orthologs

Chr.Chromosome 14 (human)^[1]

End67,600,286 bp^[1]

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PIGH
Identifiers
Aliases	PIGH, GPI-H, phosphatidylinositol glycan anchor biosynthesis class H
External IDs	OMIM: 600154; MGI: 99463; HomoloGene: 3361; GeneCards: PIGH; OMA:PIGH - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.1 Start 67,581,955 bp[1] End 67,600,286 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C3|12 35.51 cM Start 79,127,438 bp[2] End 79,136,425 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left lobe of thyroid gland right adrenal gland left adrenal gland right adrenal cortex left adrenal cortex right lobe of thyroid gland left ovary minor salivary glands right ovary Top expressed in Paneth cell transitional epithelium of urinary bladder seminal vesicula conjunctival fornix condyle epithelium of lens fossa renal corpuscle medullary collecting duct lobe of prostate More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity phosphatidylinositol N-acetylglucosaminyltransferase activity catalytic activity glycosyltransferase activity Cellular component cytoplasm endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex endoplasmic reticulum membrane integral component of membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5283 110417 Ensembl ENSG00000100564 ENSMUSG00000021120 UniProt Q14442 Q5M9N4 RefSeq (mRNA) NM_004569 NM_001363694 NM_029988 RefSeq (protein) NP_004560 NP_001350623 NP_084264 Location (UCSC) Chr 14: 67.58 – 67.6 Mb Chr 12: 79.13 – 79.14 Mb PubMed search [3] [4]
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This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.^[6]