PIGQ

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.^[5][6][7]

AliasesPIGQ, GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q, EIEE77, DEE77, MCAHS4, GPIBD19

External IDsOMIM: 605754; MGI: 1333114; GeneCards: PIGQ

Chr.Chromosome 16 (human)^[1]

End584,109 bp^[1]

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PIGQ
Identifiers
Aliases	PIGQ, GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q, EIEE77, DEE77, MCAHS4, GPIBD19
External IDs	OMIM: 605754; MGI: 1333114; GeneCards: PIGQ
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 566,995 bp[1] End 584,109 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 26,145,395 bp[2] End 26,163,910 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right uterine tube left lobe of thyroid gland right testis anterior pituitary left testis right frontal lobe body of pancreas right hemisphere of cerebellum right adrenal cortex Top expressed in fetal liver hematopoietic progenitor cell motor neuron substantia nigra fossa ciliary body endocardial cushion barrel cortex medullary collecting duct ascending aorta crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity phosphatidylinositol N-acetylglucosaminyltransferase activity glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9091 14755 Ensembl ENSG00000007541 ENSMUSG00000025728 UniProt Q9BRB3 Q9QYT7 RefSeq (mRNA) NM_148920 NM_004204 NM_001291025 NM_011822 NM_001357592 RefSeq (protein) NP_004195 NP_683721 NP_001277954 NP_035952 NP_001344521 Location (UCSC) Chr 16: 0.57 – 0.58 Mb Chr 17: 26.15 – 26.16 Mb PubMed search [3] [4]
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This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).^[7]