PIGT

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.^[5][6][7]

AliasesPIGT, MCAHS3, NDAP, PNH2, CGI-06, phosphatidylinositol glycan anchor biosynthesis class T

External IDsOMIM: 610272; MGI: 1926178; HomoloGene: 6134; GeneCards: PIGT; OMA:PIGT - orthologs

Chr.Chromosome 20 (human)^[1]

End45,456,934 bp^[1]

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PIGT
Identifiers
Aliases	PIGT, MCAHS3, NDAP, PNH2, CGI-06, phosphatidylinositol glycan anchor biosynthesis class T
External IDs	OMIM: 610272; MGI: 1926178; HomoloGene: 6134; GeneCards: PIGT; OMA:PIGT - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,416,084 bp[1] End 45,456,934 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,339,440 bp[2] End 164,350,221 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardia stromal cell of endometrium pylorus right coronary artery Descending thoracic aorta ascending aorta right auricle of heart left coronary artery apex of heart islet of Langerhans Top expressed in tail of embryo lip neural layer of retina genital tubercle superior frontal gyrus dentate gyrus of hippocampal formation granule cell muscle of thigh ventricular zone primary visual cortex yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GPI-anchor transamidase activity Cellular component integral component of membrane GPI-anchor transamidase complex endoplasmic reticulum membrane integral component of endoplasmic reticulum membrane membrane endoplasmic reticulum cytoplasm cytoplasmic vesicle Biological process attachment of GPI anchor to protein neuron differentiation GPI anchor biosynthetic process neuron apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51604 78928 Ensembl ENSG00000124155 ENSMUSG00000017721 UniProt Q969N2 Q8BXQ2 RefSeq (mRNA) NM_001184728 NM_001184729 NM_001184730 NM_015937 NM_133779 NM_001362644 NM_001362645 NM_001378795 RefSeq (protein) NP_001171657 NP_001171658 NP_001171659 NP_057021 NP_598540 NP_001349573 NP_001349574 NP_001365724 NP_001394210 Location (UCSC) Chr 20: 45.42 – 45.46 Mb Chr 2: 164.34 – 164.35 Mb PubMed search [3] [4]
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This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.^[6]