PIK3CB

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.^[5][6]

AliasesPIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

External IDsOMIM: 602925; MGI: 1922019; HomoloGene: 21250; GeneCards: PIK3CB; OMA:PIK3CB - orthologs

Chr.Chromosome 3 (human)^[1]

End138,834,928 bp^[1]

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PIK3CB
Identifiers
Aliases	PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External IDs	OMIM: 602925; MGI: 1922019; HomoloGene: 21250; GeneCards: PIK3CB; OMA:PIK3CB - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 138,652,698 bp[1] End 138,834,928 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 98,918,707 bp[2] End 99,022,674 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii internal globus pallidus endothelial cell middle temporal gyrus Epithelium of choroid plexus Brodmann area 23 lateral nuclear group of thalamus kidney tubule optic nerve pons Top expressed in granulocyte superior cervical ganglion esophagus interventricular septum zygote facial motor nucleus morula secondary oocyte lip dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 3-kinase activity protein binding insulin receptor substrate binding ATP binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity kinase activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity Cellular component cytosol phosphatidylinositol 3-kinase complex plasma membrane nucleolus nucleus midbody cytoplasm membrane intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway embryonic cleavage endocytosis positive regulation of autophagy Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway angiogenesis involved in wound healing cellular calcium ion homeostasis regulation of cell-matrix adhesion platelet activation autophagy Fc-epsilon receptor signaling pathway chemotaxis phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process positive regulation of gene expression vascular endothelial growth factor receptor signaling pathway cell adhesion response to wounding endothelial cell proliferation regulation of clathrin-dependent endocytosis T cell receptor signaling pathway platelet aggregation cell migration phosphatidylinositol-mediated signaling leukocyte migration signal transduction homophilic cell adhesion via plasma membrane adhesion molecules axon guidance phosphorylation adaptive immune response inflammatory response positive regulation of neutrophil apoptotic process innate immune response cell chemotaxis positive regulation of protein kinase B signaling phosphatidylinositol 3-kinase signaling cytokine-mediated signaling pathway protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5291 74769 Ensembl ENSG00000051382 ENSMUSG00000032462 UniProt P42338 Q8BTI9 RefSeq (mRNA) NM_001256045 NM_006219 NM_029094 RefSeq (protein) NP_001242974 NP_006210 NP_083370 Location (UCSC) Chr 3: 138.65 – 138.83 Mb Chr 9: 98.92 – 99.02 Mb PubMed search [3] [4]
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Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]^[6]