PIK3R4

PIK3R4
Identifiers
Aliases	PIK3R4, VPS15, p150, phosphoinositide-3-kinase regulatory subunit 4
External IDs	OMIM: 602610; MGI: 1922919; HomoloGene: 24678; GeneCards: PIK3R4; OMA:PIK3R4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	130,746,829 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	105,564,856 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gonad; ; anterior pituitary; ; epithelium of colon; ; right lobe of thyroid gland; ; Brodmann area 9; ; epithelium of nasopharynx; ; ventricular zone; ; mucosa of transverse colon; ; left lobe of thyroid gland;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; Epithelium of choroid plexus; ; otic vesicle; ; motor neuron; ; medullary collecting duct; ; iris; ; facial motor nucleus; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; 1-phosphatidylinositol-3-kinase activity;
Cellular component	cytosol; endosome; late endosome; phagocytic vesicle membrane; membrane; phosphatidylinositol 3-kinase complex, class III; nuclear pore; autophagosome; phosphatidylinositol 3-kinase complex, class III, type I; axoneme; nucleus-vacuole junction; cytoplasmic vesicle; phosphatidylinositol 3-kinase complex, class III, type II; microtubule cytoskeleton; intracellular membrane-bounded organelle;
Biological process	cellular response to glucose starvation; regulation of cytokinesis; phosphorylation; late endosome to vacuole transport; autophagy of peroxisome; receptor catabolic process; positive regulation of phosphatidylinositol 3-kinase activity; protein phosphorylation; phosphatidylinositol biosynthetic process; protein targeting to vacuole; toll-like receptor 9 signaling pathway; macroautophagy; phosphatidylinositol-3-phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	30849
	75669
	ENSG00000196455
	ENSMUSG00000032571
	Q99570
	Q8VD65
	NM_014602
	NM_001081309; NM_029380
	NP_055417
	NP_001074778
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.^[5]^[6]