Myelin P2 protein

PMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WUT, 3NR3, 4A1H, 4A1Y, 4A8Z, 4BVM, 4D6A, 4D6B
Identifiers
Aliases	PMP2, FABP8, M-FABP, MP2, P2, peripheral myelin protein 2, Myelin P2 protein, CMT1G
External IDs	OMIM: 170715; MGI: 102667; HomoloGene: 20589; GeneCards: PMP2; OMA:PMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	81,447,439 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	10,248,989 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; superior vestibular nucleus; ; trigeminal ganglion; ; inferior ganglion of vagus nerve; ; ventral tegmental area; ; subthalamic nucleus; ; external globus pallidus; ; pars reticulata; ; pars compacta; ; internal globus pallidus;
	Top expressed in
	blastocyst; ; morula; ; spermatocyte; ; neural layer of retina; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; zone of skin; ; testicle; ; esophagus; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fatty acid binding; cholesterol binding; protein binding; lipid binding; transporter activity;
Cellular component	cytoplasm; myelin sheath; extracellular exosome;
Biological process	membrane organization; transport;
	Sources:Amigo / QuickGO
Orthologs
	5375
	18857
	ENSG00000147588
	ENSMUSG00000052468
	P02689
	P24526
	NM_002677; NM_001348381
	NM_001030305
	NP_002668; NP_001335310
	NP_001025476
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin P2 protein also peripheral myelin protein 2, is a protein that in humans is encoded by the PMP2 gene.^[5]^[6]^[7] Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin, also present in small amounts in central nervous system (CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport in Schwann cells. Structurally, P2 belongs to the family of cytoplasmic fatty acid-binding proteins (FABPs).