POGZ

POGZ
Identifiers
Aliases	POGZ, ZNF280E, ZNF635, ZNF635m, MRD37, WHSUS, pogo transposable element with ZNF domain, pogo transposable element derived with ZNF domain
External IDs	OMIM: 614787; MGI: 2442117; GeneCards: POGZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E72, 2N3A
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,459,494 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,789,637 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; buccal mucosa cell; ; sural nerve; ; left ovary; ; pituitary gland; ; right ovary; ; anterior pituitary; ; ganglionic eminence; ; right lobe of thyroid gland;
	Top expressed in
	tail of embryo; ; Gonadal ridge; ; genital tubercle; ; otic vesicle; ; hand; ; Rostral migratory stream; ; cumulus cell; ; ciliary body; ; primitive streak; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding;
Cellular component	cytoplasm; chromosome; nucleus; nucleoplasm; cytosol; histone methyltransferase complex;
Biological process	kinetochore assembly; cell cycle; mitotic sister chromatid cohesion; cell division; regulation of transcription by RNA polymerase II; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23126
	229584
	ENSG00000143442
	ENSMUSG00000038902
	Q7Z3K3
	Q8BZH4
	NM_001194937; NM_001194938; NM_015100; NM_145796; NM_207171
	NM_001165948; NM_172683; NM_001368811; NM_001368812
	NP_001181866; NP_001181867; NP_055915; NP_665739; NP_997054
	NP_001159420; NP_766271; NP_001355740; NP_001355741
	Wikidata
View/Edit Human	View/Edit Mouse

Pogo transposable element with ZNF domain is a protein that in humans is encoded by the POGZ gene.^[5]^[6]

AliasesPOGZ, ZNF280E, ZNF635, ZNF635m, MRD37, WHSUS, pogo transposable element with ZNF domain, pogo transposable element derived with ZNF domain

External IDsOMIM: 614787; MGI: 2442117; GeneCards: POGZ

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 1 (human)^[1]

Quick facts Identifiers, Aliases ...

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The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus.

This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.^[6]

The CHAMP1 protein complex consisting of CHAMP1, POGZ and HPIα promotes heterochromatin assembly at multiple chromosomal sites, and also promotes homology-directed DNA repair of DNA double-strand breaks in these regions.^[7]

[5]

[6]

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[2]

[3]

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[7]

POGZ

Clinical significance

References

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