RNA polymerase II subunit B4

POLR2D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C35, 5IYD, 5IY8, 5IYC, 5IY6, 5IY7, 5IYA, 5IY9, 5IYB
Identifiers
Aliases	POLR2D, HSRBP4, HSRPB4, RBP4, RPB16, RNA polymerase II subunit B4, polymerase (RNA) II subunit D, RNA polymerase II subunit D, RPB4
External IDs	OMIM: 606017; MGI: 1916491; HomoloGene: 37968; GeneCards: POLR2D; OMA:POLR2D - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	127,858,155 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	31,929,754 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; left testis; ; right testis; ; pancreatic ductal cell; ; tibialis anterior muscle; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; gastrocnemius muscle; ; quadriceps femoris muscle;
	Top expressed in
	primary oocyte; ; yolk sac; ; ventricular zone; ; embryo; ; embryo; ; secondary oocyte; ; epiblast; ; endocardial cushion; ; medial ganglionic eminence; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA-directed 5'-3' RNA polymerase activity; single-stranded DNA binding; catalytic activity; single-stranded RNA binding; translation initiation factor binding;
Cellular component	P-body; RNA polymerase II, core complex; nucleus; nucleoplasm; cytosol; nuclear speck; nuclear DNA-directed RNA polymerase complex; RNA polymerase complex;
Biological process	mRNA splicing, via spliceosome; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; cell metabolism; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; positive regulation of translational initiation; mRNA export from nucleus in response to heat stress; fibroblast growth factor receptor signaling pathway; snRNA transcription by RNA polymerase II; RNA metabolic process; regulation of gene silencing by miRNA; DNA-templated transcription, initiation; transcription, DNA-templated; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5433
	69241
	ENSG00000144231
	ENSMUSG00000024258
	O15514
	Q9D7M8
	NM_004805
	NM_027002; NM_001357480
	NP_004796
	NP_081278; NP_001344409
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesPOLR2D, HSRBP4, HSRPB4, RBP4, RPB16, RNA polymerase II subunit B4, polymerase (RNA) II subunit D, RNA polymerase II subunit D, RPB4

External IDsOMIM: 606017; MGI: 1916491; HomoloGene: 37968; GeneCards: POLR2D; OMA:POLR2D - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts POLR2D, Available structures ...

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This gene encodes the fourth-largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene.^[6]

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RNA polymerase II subunit B4

References

Further reading

Related Articles

Related Articles

"Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II"

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"Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor"

"Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex"

"The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function"

"Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II"

"The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme"

"Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription"