POLR2H

DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

PDBOrtholog search: PDBe RCSB

AliasesPOLR2H, RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H

External IDsOMIM: 606023; MGI: 2384309; HomoloGene: 4540; GeneCards: POLR2H; OMA:POLR2H - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts Available structures, PDB ...

POLR2H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F3I, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2H, RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H
External IDs	OMIM: 606023; MGI: 2384309; HomoloGene: 4540; GeneCards: POLR2H; OMA:POLR2H - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,361,718 bp[1] End 184,368,596 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B1 Start 20,536,415 bp[2] End 20,541,017 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon pancreatic ductal cell right lobe of thyroid gland right uterine tube left lobe of thyroid gland right adrenal gland right adrenal cortex left adrenal cortex rectum canal of the cervix Top expressed in epiblast embryo morula embryo ventricular zone neural tube yolk sac tail of embryo ganglionic eminence ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity single-stranded DNA binding Cellular component nucleolus RNA polymerase II, core complex nucleoplasm cytosol nucleus RNA polymerase III complex RNA polymerase I complex protein-DNA complex Biological process 7-methylguanosine mRNA capping transcription elongation from RNA polymerase II promoter transcription initiation from RNA polymerase I promoter mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription-coupled nucleotide-excision repair termination of RNA polymerase I transcription transcription initiation from RNA polymerase II promoter transcription by RNA polymerase II snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5437 245841 Ensembl ENSG00000163882 ENSMUSG00000021018 UniProt P52434 Q923G2 RefSeq (mRNA) NM_001278698 NM_001278699 NM_001278700 NM_001278714 NM_001278715 NM_006232 NM_001346879 NM_145632 NM_001356423 RefSeq (protein) NP_001265627 NP_001265628 NP_001265629 NP_001265643 NP_001265644 NP_001333808 NP_006223 NP_663607 NP_001343352 Location (UCSC) Chr 3: 184.36 – 184.37 Mb Chr 16: 20.54 – 20.54 Mb PubMed search [3] [4]
Wikidata
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This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.^[5]