PPIL4

Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.^[5]

AliasesPPIL4, HDCME13P, peptidylprolyl isomerase like 4

External IDsOMIM: 607609; MGI: 1914668; HomoloGene: 12126; GeneCards: PPIL4; OMA:PPIL4 - orthologs

Chr.Chromosome 6 (human)^[1]

End149,546,043 bp^[1]

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PPIL4
Identifiers
Aliases	PPIL4, HDCME13P, peptidylprolyl isomerase like 4
External IDs	OMIM: 607609; MGI: 1914668; HomoloGene: 12126; GeneCards: PPIL4; OMA:PPIL4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,504,495 bp[1] End 149,546,043 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 7,668,655 bp[2] End 7,698,899 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon testicle left ovary gonad ventricular zone right ovary endometrium islet of Langerhans thymus Top expressed in saccule otic vesicle otic placode zygote primitive streak granulocyte pituitary gland seminal vesicula neural layer of retina blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function isomerase activity nucleic acid binding RNA binding peptidyl-prolyl cis-trans isomerase activity Cellular component nucleus nucleoplasm cytosol Biological process protein peptidyl-prolyl isomerization regulation of phosphorylation of RNA polymerase II C-terminal domain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85313 67418 Ensembl ENSG00000131013 ENSMUSG00000015757 UniProt Q8WUA2 Q9CXG3 RefSeq (mRNA) NM_139126 NM_026141 RefSeq (protein) NP_624311 NP_080417 Location (UCSC) Chr 6: 149.5 – 149.55 Mb Chr 10: 7.67 – 7.7 Mb PubMed search [3] [4]
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This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.^[5]