PPM1G

Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene.^[5][6]

AliasesPPM1G, PP2CG, PP2CGAMMA, PPP2CG, protein phosphatase, Mg2+/Mn2+ dependent 1G

External IDsOMIM: 605119; MGI: 106065; HomoloGene: 31106; GeneCards: PPM1G; OMA:PPM1G - orthologs

Chr.Chromosome 2 (human)^[1]

End27,409,591 bp^[1]

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PPM1G
Identifiers
Aliases	PPM1G, PP2CG, PP2CGAMMA, PPP2CG, protein phosphatase, Mg2+/Mn2+ dependent 1G
External IDs	OMIM: 605119; MGI: 106065; HomoloGene: 31106; GeneCards: PPM1G; OMA:PPM1G - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,381,195 bp[1] End 27,409,591 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 17.27 cM Start 31,360,008 bp[2] End 31,378,031 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis ganglionic eminence sperm ventricular zone islet of Langerhans mucosa of transverse colon gastrocnemius muscle granulocyte stromal cell of endometrium Top expressed in fetal liver hematopoietic progenitor cell spermatid ectoderm otic vesicle otic placode epiblast seminiferous tubule spermatocyte tibiofemoral joint primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein binding catalytic activity phosphoprotein phosphatase activity hydrolase activity metal ion binding cation binding Cellular component cytoplasm membrane nucleus nucleoplasm Biological process protein dephosphorylation peptidyl-threonine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5496 14208 Ensembl ENSG00000115241 ENSMUSG00000029147 UniProt O15355 Q6IAU5 Q61074 RefSeq (mRNA) NM_177983 NM_008014 RefSeq (protein) NP_817092 NP_817092.1 NP_032040 Location (UCSC) Chr 2: 27.38 – 27.41 Mb Chr 5: 31.36 – 31.38 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.^[6]