PPP1CB

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.^[5]

AliasesPPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta, NSLH2, PPP1beta, PP1c, MP

External IDsOMIM: 600590; MGI: 104871; HomoloGene: 37659; GeneCards: PPP1CB; OMA:PPP1CB - orthologs

Chr.Chromosome 2 (human)^[1]

End28,802,940 bp^[1]

Quick facts Identifiers, Aliases ...

PPP1CB
Identifiers
Aliases	PPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta, NSLH2, PPP1beta, PP1c, MP
External IDs	OMIM: 600590; MGI: 104871; HomoloGene: 37659; GeneCards: PPP1CB; OMA:PPP1CB - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 28,751,640 bp[1] End 28,802,940 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 32,616,187 bp[2] End 32,674,777 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon amniotic fluid buccal mucosa cell ventricular zone Descending thoracic aorta popliteal artery tibial arteries ascending aorta caput epididymis ganglionic eminence Top expressed in blood Gonadal ridge atrium lobe of cerebellum pineal gland olfactory tubercle ventral tegmental area medial vestibular nucleus cerebellar vermis parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function phosphoprotein phosphatase activity myosin phosphatase activity phosphatase activity protein serine/threonine phosphatase activity metal ion binding myosin-light-chain-phosphatase activity protein binding protein kinase binding hydrolase activity Cellular component cytoplasm cytosol focal adhesion nucleoplasm protein phosphatase type 1 complex glycogen granule PTW/PP1 phosphatase complex nucleolus extracellular exosome nucleus plasma membrane Biological process rhythmic process protein dephosphorylation circadian regulation of gene expression cell division regulation of cell adhesion G2/M transition of mitotic cell cycle regulation of circadian rhythm glycogen metabolic process regulation of glycogen biosynthetic process cell cycle regulation of glycogen catabolic process entrainment of circadian clock by photoperiod carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5500 19046 Ensembl ENSG00000213639 ENSMUSG00000014956 UniProt P62140 P62141 RefSeq (mRNA) NM_206877 NM_002709 NM_206876 NM_172707 RefSeq (protein) NP_002700 NP_996759 NP_766295 Location (UCSC) Chr 2: 28.75 – 28.8 Mb Chr 5: 32.62 – 32.67 Mb PubMed search [3] [4]
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The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.^[6]