PPP1R12B

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.^[5][6]

AliasesPPP1R12B, MYPT2, PP1bp55, protein phosphatase 1 regulatory subunit 12B

External IDsOMIM: 603768; MGI: 1916417; HomoloGene: 136757; GeneCards: PPP1R12B; OMA:PPP1R12B - orthologs

Chr.Chromosome 1 (human)^[1]

End202,592,706 bp^[1]

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PPP1R12B
Identifiers
Aliases	PPP1R12B, MYPT2, PP1bp55, protein phosphatase 1 regulatory subunit 12B
External IDs	OMIM: 603768; MGI: 1916417; HomoloGene: 136757; GeneCards: PPP1R12B; OMA:PPP1R12B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,348,699 bp[1] End 202,592,706 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 134,682,396 bp[2] End 134,883,680 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein myocardium of left ventricle right coronary artery cardiac muscle tissue of right atrium right ventricle popliteal artery tibial arteries tail of epididymis thoracic aorta ascending aorta Top expressed in Rostral migratory stream ascending aorta muscle of thigh aortic valve soleus muscle extraocular muscle digastric muscle temporal muscle vastus lateralis muscle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme activator activity protein binding protein kinase binding phosphatase regulator activity enzyme inhibitor activity Cellular component cytoplasm cytosol A band Z discdkac nucleoplasm cytoskeleton Biological process regulation of muscle contraction positive regulation of catalytic activity signal transduction regulation of catalytic activity negative regulation of catalytic activity G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4660 329251 Ensembl ENSG00000077157 ENSMUSG00000073557 UniProt O60237 Q8BG95 RefSeq (mRNA) NM_001167857 NM_001167858 NM_001197131 NM_002481 NM_032103 NM_032104 NM_032105 NM_001331029 NM_001081307 NM_001368827 NM_001368829 RefSeq (protein) NP_001161329 NP_001161330 NP_001184060 NP_001317958 NP_002472 NP_115286 NP_115287 NP_001074776 NP_001355756 NP_001355758 Location (UCSC) Chr 1: 202.35 – 202.59 Mb Chr 1: 134.68 – 134.88 Mb PubMed search [3] [4]
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Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.^[6]