PPP1R8

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesPPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8

External IDsOMIM: 602636; MGI: 2140494; HomoloGene: 8555; GeneCards: PPP1R8; OMA:PPP1R8 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts Available structures, PDB ...

PPP1R8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V4Y
Identifiers
Aliases	PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8
External IDs	OMIM: 602636; MGI: 2140494; HomoloGene: 8555; GeneCards: PPP1R8; OMA:PPP1R8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 27,830,782 bp[1] End 27,851,676 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,554,240 bp[2] End 132,570,480 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone islet of Langerhans ganglionic eminence stromal cell of endometrium smooth muscle tissue lymph node C1 segment granulocyte mucosa of sigmoid colon Top expressed in somite mandibular prominence maxillary prominence epiblast medial ganglionic eminence abdominal wall hand otic vesicle condyle human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase inhibitor activity DNA binding protein binding RNA binding protein phosphatase inhibitor activity nuclease activity endonuclease activity ribonuclease E activity hydrolase activity mRNA binding protein phosphatase regulator activity Cellular component cytoplasm nuclear speck nucleoplasm spliceosomal complex nucleus Biological process regulation of transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis mRNA processing RNA catabolic process transcription, DNA-templated RNA splicing cell population proliferation RNA phosphodiester bond hydrolysis negative regulation of protein dephosphorylation negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity production of miRNAs involved in gene silencing by miRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5511 100336 Ensembl ENSG00000117751 ENSMUSG00000028882 UniProt Q12972 Q8R3G1 RefSeq (mRNA) NM_138558 NM_002713 NM_014110 NM_001290725 NM_146154 NM_001355198 NM_001355199 RefSeq (protein) NP_002704 NP_054829 NP_612568 NP_001277654 NP_666266 NP_001342127 NP_001342128 Location (UCSC) Chr 1: 27.83 – 27.85 Mb Chr 4: 132.55 – 132.57 Mb PubMed search [3] [4]
Wikidata
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This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.^[7]