PPP1R9B

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.^[5][6]

AliasesPPP1R9B, PPP1R6, PPP1R9, SPINO, Spn, protein phosphatase 1 regulatory subunit 9B

External IDsOMIM: 603325; MGI: 2387581; HomoloGene: 32787; GeneCards: PPP1R9B; OMA:PPP1R9B - orthologs

Chr.Chromosome 17 (human)^[1]

End50,150,677 bp^[1]

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PPP1R9B
Identifiers
Aliases	PPP1R9B, PPP1R6, PPP1R9, SPINO, Spn, protein phosphatase 1 regulatory subunit 9B
External IDs	OMIM: 603325; MGI: 2387581; HomoloGene: 32787; GeneCards: PPP1R9B; OMA:PPP1R9B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,133,737 bp[1] End 50,150,677 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 94,881,861 bp[2] End 94,897,725 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte cingulate gyrus anterior cingulate cortex monocyte right frontal lobe amygdala Brodmann area 9 prefrontal cortex nucleus accumbens Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex neural layer of retina granulocyte lip ventricular zone cerebellar cortex esophagus thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 1 binding protein binding protein phosphatase inhibitor activity actin binding actin filament binding Cellular component cytoplasm cell projection membrane filopodium adherens junction plasma membrane dendritic spine synapse nucleoplasm ruffle membrane cell junction protein phosphatase type 1 complex cytoskeleton nucleus lamellipodium postsynaptic density actin cytoskeleton dendrite Biological process cell differentiation regulation of opioid receptor signaling pathway filopodium assembly regulation of cell growth by extracellular stimulus modulation of chemical synaptic transmission nervous system development multicellular organism development regulation of cell population proliferation negative regulation of cell growth RNA splicing cellular response to morphine cell migration regulation of exit from mitosis negative regulation of phosphoprotein phosphatase activity actin filament organization calcium-mediated signaling neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84687 217124 Ensembl ENSG00000108819 ENSMUSG00000038976 UniProt Q96SB3 Q6R891 RefSeq (mRNA) NM_032595 NM_172261 RefSeq (protein) NP_115984 NP_758465 Location (UCSC) Chr 17: 50.13 – 50.15 Mb Chr 11: 94.88 – 94.9 Mb PubMed search [3] [4]
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Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM]^[6]